规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50μL*10mM(DMSO) | ¥119随货¥89 | 咨询 | |
100μL*10mM(DMSO) | ¥169随货¥119 | 咨询 | |
250μL*10mM(DMSO) | ¥299随货¥209 | 咨询 | |
500μL*10mM(DMSO) | ¥429随货¥309 | 咨询 | |
10mM*1mL(DMSO) | ¥678 | 咨询 | |
5mg | ¥554 | 咨询 | |
10mg | ¥882 | 咨询 | |
25mg | ¥1764 | 咨询 | |
50mg | ¥3024 | 咨询 | |
100mg | ¥4788 | 咨询 |
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描述 | The chemokine receptor CCR2, a G protein-coupled receptor implicated in numerous chronic inflammatory diseases, has led to the development of various small molecule antagonists. CCR2-RA-[R] effectively displaces [125I]CCL2 from CCR2 with a pIC50 value of 6.1, while its pKD for CCR2 and CCR5 are 8.8±0.1 and 7.0±0.1 respectively[2]. CCR2-RA-[R] inhibits CCR2 non-competitively by preventing activation-associated conformational changes and the formation of the G protein-binding interface. The drug-binding pocket of CCR2-RA-[R] is notably enclosed and features a beneficial mix of hydrophobic and polar characteristics that enhance its "druggability"[3]. |
体外研究 | The chemokine receptor CCR2, a G protein-coupled receptor implicated in numerous chronic inflammatory diseases, has led to the development of various small molecule antagonists. CCR2-RA-[R] effectively displaces [125I]CCL2 from CCR2 with a pIC50 value of 6.1, while its pKD for CCR2 and CCR5 are 8.8±0.1 and 7.0±0.1 respectively[2]. CCR2-RA-[R] inhibits CCR2 non-competitively by preventing activation-associated conformational changes and the formation of the G protein-binding interface. The drug-binding pocket of CCR2-RA-[R] is notably enclosed and features a beneficial mix of hydrophobic and polar characteristics that enhance its "druggability"[3]. |
计算器 | ||||
存储液制备 | ![]() | 1mg | 5mg | 10mg |
1 mM 5 mM 10 mM | 2.84mL 0.57mL 0.28mL | 14.21mL 2.84mL 1.42mL | 28.43mL 5.69mL 2.84mL |
CAS号 | 512177-83-2 |
分子式 | C18H19ClFNO3 |
分子量 | 351.8 |
别名 | |
运输 | 蓝冰 |
存储条件 | In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,2-8°C |
溶解方案 | DMSO: 35 mg/mL(99.49 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |